Enalaprilat

inquiry

Cat No.

CEI-0347

Description

Enalaprilat

CAS_No

84680-54-6

Molecular Weight

348.4

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

ACE

Molecular Formula

C18H24N2O5.2H2O

Solubility

DMSO 70 mg/mL, Water 5 mg/mL, Ethanol 1 mg/mL

In vitro

Enalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykiningiotensin I selectivity ratio of 1.00 calculated from double displacement experiments. Enalaprilat has the strong inhibitory effect on Abeta42-to-Abeta40-converting activity found in the N-domain of ACE, exhibiting a 10-fold lower IC50 (0.003~0.01 uM) than captopril (0.03~0.1 uM). Enalaprilat (100 nM) blocks protein kinase C epsilon by directly activating bradykinin B1 receptor at the canonical Zn2+ binding site, leading to prolonged nitric oxide (NO) production in cytokine-treated human lung microvascular endothelial cells.

Name:

Email *

Phone:*

Company/Institution:

Country or Region:

Quantity:

Services & Products Interested *

Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Products

Online Inquiry