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FK-506

Cat No.
CEI-0540
Description
A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12), leading to increase in the release of sarcoplamic reticulum-derived calcium. FK506 and rapamycin, but not cytosporin inhibit aldosterone-stimulated sodium transport in A6 cells.
Alias
Tacrolimus
Appearance
White solid
Product Overview
A potent immunosuppresant
CAS No.
104987-11-3
Molecular Weight
805
Purity
>98%
Storage
-20 centigrade
Synonyms
Tacrolimus
Targets
immunosuppresant
Molecular Formula
C₄₄H₆₉NO₁₂
Chemical Name
Tacrolimus
Solubility
DMSO (>1 mg/ml) and EtOH (>1 mg/ml)
Shipping Conditions
Gel pack
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