FK-866

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Cat No.

CEI-0591

Description

Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50 = ~1 nM).

Appearance

White to off-white solid

Product Overview

A highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT)

CAS_No

658084-64-1

Molecular Weight

718.1

Purity

>97% by HPLC

Storage

-20 centigrade

Targets

NAMPT

Molecular Formula

C₂₄H₂₉N₃O₂

Chemical Name

N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide

Solubility

DMSO or EtOH

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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