FMK

inquiry

Cat No.

CEI-0923

Description

FMK is a potent and selective inhibitor of p90 ribosomal protein S6 kinaseRSK2 (wt) with IC50 of 15 nM, >600- and 200-fold selectivity for RSK2 than the C436V and T493M mutants.

CAS_No

821794-92-7

Molecular Weight

342.37

Storage

2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO.

Targets

RSK2

IC50

15 nM

Molecular Formula

C18H19FN4O2

Chemical Name

Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-

Solubility

DMSO mg/mL; Water mg/mL; Ethanol mg/mL

In vitro

FMK inhibits the activity of RSK2 with IC50 of 15 nM. FMK suppresses EGF induced Ser386 phosphorylation of endogenous RSK2 in serum-starved COS-7 cells with EC50 of ~200 nM. Pretreatment of myocytes with FMK before exposure to the α1-adrenoceptor agonist phenylephrine inhibited RSK C-terminal kinase activity and thereby RSK N-terminal kinase activation, without affecting MEK or ERK activation. Pretreatment of myocytes with fmk also inhibited phenylephrine-induced increases in NHE1 phosphorylation and the rate of NHE1-mediated H+ efflux under conditions of intracellular acidosis.

Name:

Email *

Phone:*

Company/Institution:

Country or Region:

Quantity:

Services & Products Interested *

Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Products

Online Inquiry