Garcinol

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Cat No.

CEI-0598

Description

Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 µM) and PCAF (IC50 = 5 µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions. Garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.

Alias

Camboginol

Appearance

Yellow solid

Product Overview

A potent histone acetyltransferases (HATs) p300 inhibitor

CAS_No

78824-30-3

Molecular Weight

480.9

Purity

>98% by TLC

Storage

-20 centigrade

Synonyms

Camboginol

Targets

EP300, KAT2B

Molecular Formula

C 38 H 50 O 6

Solubility

DMSO (100 mM) or H2O (100 mM)

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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