GDC-0941

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Cat No.

CEI-0125

Description

GDC-0941 can inhibit p110-alpha with IC50 of less than 10 nM.

CAS_No

957054-30-7

Molecular Weight

513.64

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

p110-alpha

Molecular Formula

C23H27N7O3S2

Chemical Name

2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

Solubility

DMSO 44 mg/mL Water

In vitro

GDC-0941, a class I selective PI3K inhibitor, can inhibit p110-alpha with IC50 of less than 10 nM. GDC-0941 showed a high efficacy of antitumor activity in two gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines, A549 and H460,as H460 cells with activating mutations of PIK3CA were relatively more sensitive to GDC-0941 than A549 cells with wild-type PIK3CA.

In vivo

In GIST xenograft models, GDC-0941 causes tumor growth stabilization, inhibiting tumor cell proliferation, but did not induce apoptosis. Combination of DOX with the specific PI3K inhibitor GDC-0941 can lead to caspase 3 activation in xenografts of sarcoma cells.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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