GW-441756

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Cat No.

CEI-0964

Description

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Blocks TrkA-mediated gammaH2AX production and apoptosis in TrkA-overexpressing cells. Cell permeable.

Abbr

GW-441756(NGFR)

Alias

1, 3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3, 2-b]pyridin-2-one

Appearance

Orange powder

Product Overview

NGFR inhibitor

CAS_No

504433-23-2

Molecular Weight

275.1

Purity

98% (TLC: 5% CH3OH: CH2Cl2; Rf=0.4) mixture of E

Synonyms

1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Targets

NGFR

Molecular Formula

C17H13N3O

Solubility

May be dissolved in DMSO (25 mg/ml); or Ethanol (100 mg/ml)

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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