GW-5074

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Cat No.

CEI-0965

Description

Specific inhibitor of cRaf-1 kinase (IC50=9 nM). Acts at > 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective activity. Cell permeable.

Abbr

GW-5074(RAF1)

Alias

3-(3, 5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1, 3-dihydro-indol-2-one

Appearance

Off white powder

Product Overview

c-Raf1 inhibitor

CAS_No

220904-83-6

Molecular Weight

520.9

Purity

98% (TLC); NMR (Conforms)

Synonyms

3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one

Targets

c-Raf1

Molecular Formula

C15H8Br2INO2

Melting Point

267-268ºC

Solubility

May be dissolved in DMSO (50 mg/ml)

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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