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Heptelidic Acid

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Cat No.
CEI-0490
Description
A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols.
Alias
Koningic acid; Avocettin; FO-4443; BRN 5091359
Appearance
White solid
Product Overview
A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor
CAS_No
74310-84-2
Molecular Weight
327.42
Purity
>96% by HPLC
Storage
-20 centigrade
Synonyms
Koningic acid; Avocettin; FO-4443; BRN 5091359
Targets
GAPDH
Molecular Formula
C15H20O5
Solubility
H₂O
Shipping Conditions
Gel pack
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