Histidyl-tRNA Synthetase from Human, Recombinant

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Cat No.

NATE-0848

Description

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.

Abbr

HRS, Recombinant (Human)

Alias

HRS

Source

E. coli

Species

Human

Appearance

Sterile Filtered clear solution

Product Overview

Histidyl-tRNA Synthetase Human Recombinant produced in E. coli is a single, nonglycosylated, polypeptide chain having a molecular mass of 55 kDa. The Histidyl-tRNA Synthetase is purified by proprietary chromatographic techniques.

Enzyme Commission Number

EC 6.1.1.21

CAS_No

9068-78-4

Purity

Greater than 90.0% as determined by both (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Stability

Histidyl-tRNA Synthetase although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.

Buffer

The protein solution contains 150mM NaCl and 10mM sodium phosphate containing 0.1% NaN3 (pH 7.2).

Synonyms

Histidyl-tRNA synthetase; EC 6.1.1.21; Histidine-tRNA ligase; HisRS; HRS; FLJ20491; JO-1

"HRS" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
EXWM-5653	histidine-tRNA ligase	EC 6.1.1.21	9068-78-4		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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