IKK-3 Inhibitor

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Cat No.

CEI-1368

Product Overview

An IKK-3 Inhibitor. The NF-κ B/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory Iκ B proteins. NF-κ B is activated upon degradation of Iκ B following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κ B. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.

CAS_No

862812-98-4

Molecular Weight

469.53

Storage

Store at -20°C

Targets

IKK-3

Molecular Formula

C22H19N3O5S2

Chemical Name

5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile

Solubility

DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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