Insulin Degrading Enzyme (His•Tag) from Rat, Recombinant

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Cat No.

NATE-0849

Description

Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over sixty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently. This discovery revealed considerable amino acid sequence similarity between IDE and the previously characterized bacterial protease pitrilysin, suggesting a common proteolytic mechanism.

Abbr

IDE, Recombinant (Rat)

Alias

IDE

Source

S. frugiperda

Species

Rat

Product Overview

Recombinant, rat insulin degrading enzyme fused to a His•Tag sequence and expressed in S. frugiperda insect cells. A metalloprotease that degrades insulin and a variety of other peptides including amyloid peptides.

Form

Liquid

Enzyme Commission Number

EC 3.4.24.56

Activity

>3 U/mg protein

Molecular Weight

110 kDa

Purity

>90% by SDS-PAGE

Unit Definition

One unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.

Storage

< -70°C

Buffer

In 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.

Synonyms

IDE; Insulin-degrading enzyme; insulysin; insulin protease

"IDE" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
EXWM-4338	insulysin	EC 3.4.24.56	9013-83-6		Inquiry

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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