Itraconazole

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Cat No.

CEI-0524

Description

A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that Itraconazole inhibits Hedgehog (Hh) signaling pathway activity (IC50 = 0.8 µM) as well as blocks the VEGFR2 glycosylation, trafficking, and signaling in endothelial cells.

Alias

Oriconazole, R51211, Sporanox

Appearance

Yellow solid

Product Overview

An antifungal agent and Hh signaling inhibitor

CAS_No

84625-61-6

Molecular Weight

489.99

Purity

>98% by HPLC

Storage

-20 centigrade

Synonyms

Oriconazole, R51211, Sporanox

Targets

Molecular Formula

C 35 H 38 Cl 2 N 8 O 4

Chemical Name

(2R,4S)-rel-1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one

Solubility

DMSO (>20 mg/ml)

Shipping Conditions

Gel pack

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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