JAK2 Inhibitor II

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Cat No.

CEI-1061

Description

A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.

Abbr

JAK2 Inhibitor II(JAK2)

Alias

JTK10, THCYT3

CAS_No

1837-91-8

Molecular Weight

557.5

Purity

> 97% by GC

Storage

+2 centigrade to +8 centigrade

Synonyms

JTK10, THCYT3

Targets

JAK2

Molecular Formula

C6H6Br6

Chemical Name

1,2,3,4,5,6-Hexabromocyclohexane

Solubility

DMSO

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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