JAK2 Inhibitor V, Z3

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Cat No.

CEI-1063

Description

A cell-permeable pyridinylbutanone compound that inhibits cellular autophosphorylation of both the wild-type Jak2 and the constitutively active V167F mutant (IC50 = 15 & 28 µM, respectively, with WT- & V617F-transfected BSC-40 cells), while exhiting no effect against cellular Tyk2 autophosphorylation in COS cells or c-Src kinase in cell-free kinase assays. Z3 suppresses the Jak2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients.

Abbr

JAK2 Inhibitor V, Z3(JAK2, the constitutively active V167F mutant)

Alias

JTK10, THCYT3

CAS_No

195371-52-9

Molecular Weight

344.5

Purity

>97% by HPLC

Storage

+2 centigrade to +8 centigrade

Synonyms

JTK10, THCYT3

Targets

Jak2, the constitutively active V167F mutant

IC50

15µM, 28 µM

Molecular Formula

C23H24N2O

Chemical Name

2-Methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one

Solubility

DMSO or EtOH

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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