JAK3 Inhibitor VI

inquiry

Cat No.

CEI-1067

Description

A cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005).

Abbr

JAK3 Inhibitor VI(JAK3, CTLL, human T-cells)

Alias

JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

CAS_No

856436-16-3

Molecular Weight

383.4

Purity

>98% by HPLC

Storage

+2 centigrade to +8 centigrade

Synonyms

JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

Targets

JAK-3, mouse CTLL, human T-cells

IC50

27 nM, 760 nM, 250 nM

Molecular Formula

C18H13N3O • MeSO3H

Solubility

DMSO or H2O

Name:

Email *

Phone:*

Company/Institution:

Country or Region:

Quantity:

Services & Products Interested *

Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Products

Online Inquiry