JNJ-38158471

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Cat No.

CEI-1132

Description

It is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM. It also inhibits closely related tyrosine kinases, Ret (180nM) and Kit (500nM). It has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.

Abbr

JNJ-38158471(KDR)

Alias

CD309, FLK1, VEGFR, VEGFR2

CAS_No

951151-97-6

Molecular Weight

364.79

Purity

> 95%

Stability

2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO

Storage

4 centigrade

Synonyms

CD309, FLK1, VEGFR, VEGFR2

Targets

VEGFR-2

IC50

40nM

Molecular Formula

C15H17ClN6O3

Chemical Name

(E)-1-(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)-2-chlorophenyl)-3-ethylurea

Solubility

DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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