KX2-391

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Cat No.

CEI-0263

Description

KX2-391 can inhibit Src with IC50 of 72 nM.

CAS_No

897016-82-9

Molecular Weight

431.53

Purity

>99%

Storage

2 years at -20 centigrade

Targets

Src

Molecular Formula

C26H29N3O3

Chemical Name

N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide

Solubility

DSMO 86 mg/mL Water

In vitro

As a small molecule and non-ATP competitive inhibitor, KX2-391 can inhibit Src tyrosine kinase signaling inhibitor with an IC50 of 72 nM by targeting the substrate binding pocket of Src. KX2-391 can also inhibit tubulin polymerization. For cell lines KX2-391 can inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation.

In vivo

In pre-clinical animal models of cancer, orally administered KX2-391 was shown to inhibit primary tumor growth and to suppress metastasis. In combination with certain chemotherapeutic agents, KX2-391 can reduce the doses of some current cytotoxic agents. KX2-391 is currently in Phase-2 testing for solid tumors.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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