Leptomycin B

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Cat No.

CEI-0451

Description

A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.

Alias

LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B

Appearance

White to yellowish solid

Product Overview

An inhibitor of nuclear export

CAS_No

87081-35-4

Molecular Weight

472.54

Purity

>98% by HPLC

Storage

-20 centigrade

Synonyms

LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B

Targets

XPO1

Molecular Formula

C₃₃H₄₈O₆

Solubility

DMSO (>15 mg/ml) or H₂O (

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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