Linsitinib (OSI-906)

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Cat No.

CEI-0045

Description

Linsitinib (OSI-906) can inhibit IGF-1R and IR with IC50 of 35 nM and 75 nM.

CAS_No

867160-71-2

Molecular Weight

421.49

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

IGF-1R, IR

Molecular Formula

C26H23N5O

Chemical Name

(1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol

Solubility

DMSO 84 mg/mL Water

In vitro

Linsitinib (OSI-906) is a dual inhibitor of the IGF-1 receptor and insulin receptor. OSI-906 shows inhibition to hepatocellular carcinoma (HCC).

In vivo

A subset of HCC tumor cell lines was sensitive to OSI-906, where inhibition of the AKT pathway, but not the extracellular signal-regulated kinase (ERK) pathway, was associated with sensitivity.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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