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LKB1 (AAK1 dual inhibitor)
Cat No.
CEI-1399
Product Overview
LKB1 is a selective inhibitor of Pim-1 kinase with Kd value of 35 nM. Pim-1 (proto-oncogene serine/threonine-protein kinase) is a proto-oncogene encodes by PIM1 gene and is reported to play an important role in multiple human cancers. Initially, pim-1 is reported to be expressed in spleen, thymus, bone marrow, prostate, oral epithelial cells, etc. Recently, the high expression of pim-1 has been identified in several isolated human cancer cells and been shown to involve in the cell cycle progression, apoptosis, transcriptional activation and many general signal transduction pathways. Therefore, investigation of the inhibition of pim-1 by low molecular weight compounds as a part of anticancer therapeutic strategies needs more attention and progress.
CAS No.
1093222-27-5
Molecular Weight
339.36
Purity
0.9901
Storage
Store at -20°C
Synonyms
LKB1/AAK1 dual inhibitor
Targets
Pim-1 kinase
Molecular Formula
C20H13N5O
Chemical Name
N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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