LY2157299

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Cat No.

CEI-0310

Description

LY2157299 can TGF-beta receptor I with IC50 of 56 nM.

CAS_No

700874-72-2

Molecular Weight

369.42

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

TGF-beta receptor I

Molecular Formula

C22H19N5O

Chemical Name

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide

Solubility

DMSO 74 mg/mL Water

In vitro

LY2157299 is a new type I receptor TGF-beta kinase inhibitor. LY-2157299 could inhibit TGF-beta-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells. In vivo administration of LY-2157299 ameliorated anemia in a TGF-beta overexpressing transgenic mouse model of bone marrow failure. Treatment with LY-2157199 stimulated hematopoiesis from primay MDS bone marrow specimens.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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