LY2784544

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Cat No.

CEI-0190

Description

LY2784544

CAS_No

1229236-86-5

Molecular Weight

469.94

Purity

>99%

Storage

2 years at -20 centigrade

Targets

JAK2 V617F

Molecular Formula

C23H25ClFN7O

Solubility

In vitro

LY2784544 potently inhibited the JAK2 V617F-STAT5 signaling with IC50 of 55 nM, but the IC50 for inhibiting wild type JAK2 is 2.26 uM. LY2784544 selectively inhibit the JAK2 V617F-driven cell proliferation with IC50 of 68 nM.In Ba/F3 cell model, LY2784544 can inhibit JAK2 V617F signaling and induce apoptosis with EC50 of 113 nM.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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