LY335979 (Zosuquidar 3HCl)

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Cat No.

CEI-0254

Description

LY335979 can potently inhibit P-gp with Ki of 59 nM.

Alias

RS-33295-198

CAS_No

167465-36-3

Molecular Weight

636.99

Purity

>99%

Storage

2 years at -20centigrade Powder

Synonyms

RS-33295-198

Targets

P-gp

Molecular Formula

C32H31F2N3O2.3HCl

Chemical Name

1-Piperazineethanol, 4-[(1aalpha,6alpha,10balpha)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-alpha-[(5-quinolinyloxy)methyl]-,trihydrochloride

Solubility

DMSO 127 mg/mL Water 23 mg/mL Ethanol

In vitro

As a selective inhibitor of P-gp, LY335979 can potently inhibit P-gp with Ki of 59 nM, but does not modulate MRP-mediated resistance by MRP1 (ABCC1) and MRP2 (ABCC2). LY335979 is 500-1500 times more potent than cyclosporin A or verapamil in restoring Pgp substrate accumulation in the MDR cell line HL60/VCR. LY335979 could effectively block Pgp function on isolated CD56(+) lymphocytes and CD56(+) lymphocytes in whole blood with IC50 of 1.2 nM and 174 nM.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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