Manumycin A

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Cat No.

CEI-0480

Description

An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC50 = 180 µM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.

Alias

NSC-622141; UFC 1C

Appearance

Off-white solid

Product Overview

A potent ras farnesyltransferase (FTase) inhibitor

CAS_No

52665-74-4

Molecular Weight

302.78

Purity

>90% by NMR

Storage

-20 centigrade

Synonyms

NSC-622141; UFC 1C

Targets

FNTB

Molecular Formula

C 31 H 38 N 2 O

Solubility

DMSO (100 mM)

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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