MG-132

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Cat No.

CEI-0620

Description

A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC50 = 3 µM). Prevents γ-secretase cleavage.

Alias

Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

Appearance

Orange solid

Product Overview

A proteasome inhibitor

CAS_No

133407-82-6

Molecular Weight

362.42

Purity

>95% by HPLC

Storage

-20 centigrade

Synonyms

Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

Targets

protease

Molecular Formula

C₂₆H₄₁N₃O₅

Solubility

DMSO

Shipping Conditions

"Protease" Total Products Page

Enzymes

Catalog	Product Name	CAS No.	Source	Price
NATE-0631	Native Aspergillus oryzae Protease	9001-92-7	Aspergillus oryzae	Inquiry
NATE-0630	Protease S from Pyrococcus furiosus, Recombinant		Bacillus sp.	Inquiry
NATE-0629	Native Rhizopus sp. Protease	9001-92-7	Rhizopus sp.	Inquiry
NATE-0628	Native Bovine Protease	9001-92-7	bovine pancreas	Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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