MK-1775

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Cat No.

CEI-0291

Description

MK-1775 can inhibit Wee1 kinase with IC50 of 5.2 nM.

CAS_No

955365-80-7

Molecular Weight

500.6

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

Wee1 kinase

Molecular Formula

C27H32N8O2

Chemical Name

2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one

Solubility

DMSO 80 mg/mL Water

In vitro

MK-1775, a small molecule Wee1 inhibitor, can inhibit Wee1 which is involved in G(2) checkpoint signaling. MK-1775 inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cells. MK-1775 abrogates G(2) DNA damage checkpoint, leading to apoptosis.

In vivo

MK-1775 can abrogate the radiation-induced G(2) checkpoint and enhanced radiosensitivity in established glioblastoma cell lines in vitro and in vivo.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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