Nα-Fmoc-2-(trifluoromethyl)-L-phenylalanine

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Cat No.

CEGZ-6904

Description

Nα-Fmoc-2-(trifluoromethyl)-L-phenylalanine is an Fmoc-protected unnatural phenylalanine derivative bearing a trifluoromethyl substituent at the ortho position of the aromatic ring. It is used as a building block in Fmoc solid-phase peptide synthesis.

Applications

Used in solid-phase peptide synthesis for the preparation of fluorinated peptide analogues in structure-activity relationship studies, medicinal chemistry, and fluorine-19 NMR-based biochemical research.

Product Overview

The trifluoromethyl group is strongly electron-withdrawing and lipophilic, and fluorinated phenylalanine residues are introduced into peptides to modulate hydrophobic interactions, metabolic stability, and binding affinity, as well as to serve as probes in fluorine-19 NMR studies.

CAS_No

352523-16-1

Molecular Weight

455.4

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

Fmoc-2-(trifluoromethyl)-L-phenylalanine; N-(9-fluorenylmethoxycarbonyl)-2-trifluoromethyl-L-phenylalanine

Molecular Formula

C25H20F3NO4

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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