Nα-Fmoc-D-glutamic Acid γ-tert-Butyl Ester

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Cat No.

CEGZ-6888

Description

Nα-Fmoc-D-glutamic acid γ-tert-butyl ester is a side-chain protected D-glutamic acid derivative used as a building block in Fmoc solid-phase peptide synthesis. The Fmoc group protects the α-amino function and is removed under mild basic conditions, while the tert-butyl ester masks the γ-carboxyl group and is cleaved during final acidolytic deprotection.

Applications

Used as a building block in solid-phase and solution-phase peptide synthesis, particularly for the preparation of protease-resistant peptides containing D-glutamic acid residues, and in medicinal chemistry research.

Product Overview

This compound is a protected form of the non-natural D-enantiomer of glutamic acid. Incorporation of D-amino acids into peptide sequences is a widely used strategy to improve proteolytic stability, modulate conformation, and enhance the biological half-life of peptide-based molecules.

CAS_No

104091-08-9

Molecular Weight

425.5

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

Fmoc-D-glutamic acid 5-tert-butyl ester; N-(9-fluorenylmethoxycarbonyl)-D-glutamic acid γ-tert-butyl ester

Molecular Formula

C24H27NO6

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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