Nα-Fmoc-L-lysine [AEEA-AEEA-γ-Glu(OtBu)] Side-Chain Derivative

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Cat No.

CEGZ-6950

Description

Nα-Fmoc-L-lysine [AEEA-AEEA-γ-Glu(OtBu)] side-chain derivative is a multifunctional lysine building block in which the ε-amino group carries a preassembled hydrophilic spacer composed of two aminoethoxyethoxyacetyl (AEEA) units linked to a γ-glutamic acid tert-butyl ester. The α-amino group is Fmoc-protected and the α-carboxyl group is free for coupling.

Applications

Used in solid-phase peptide synthesis for the introduction of hydrophilic spacer-bearing lysine residues in the preparation of lipidated and long-acting peptide analogues for pharmaceutical research.

Product Overview

Preassembled side-chain building blocks of this type are used to introduce long, hydrophilic spacer arms at defined positions of peptide sequences in a single coupling step, a strategy widely applied in the design of long-acting peptide therapeutics.

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

Fmoc-Lys(AEEA-AEEA-gamma-Glu(OtBu))-OH; Fmoc-protected lysine bearing a bis(aminoethoxyethoxy)acetyl and γ-glutamyl tert-butyl ester side chain

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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