Nα-Fmoc-Nin-Boc-α-methyl-L-tryptophan

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Cat No.

CEGZ-6897

Description

Nα-Fmoc-Nin-Boc-α-methyl-L-tryptophan is a protected α-methylated tryptophan derivative for Fmoc solid-phase peptide synthesis. The Boc group protects the indole nitrogen, while the α-methyl substituent introduces a quaternary α-carbon that restricts backbone conformational flexibility.

Applications

Applied in solid-phase peptide synthesis for the preparation of conformationally constrained, protease-resistant peptide analogues containing α-methyltryptophan residues.

Product Overview

α-Methyl amino acids are valuable in peptide design because the additional α-substituent stabilizes specific secondary structures, increases resistance to proteolytic enzymes, and can improve the pharmacological properties of peptide-based compounds.

CAS_No

1315449-98-9

Molecular Weight

540.6

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

Fmoc-α-methyl-L-tryptophan(Boc); Nα-(9-fluorenylmethoxycarbonyl)-Nin-tert-butoxycarbonyl-α-methyl-L-tryptophan

Molecular Formula

C32H32N2O6

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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