Nα-Fmoc-S-acetamidomethyl-L-cysteine

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Cat No.

CEGZ-6962

Description

Nα-Fmoc-S-acetamidomethyl-L-cysteine is a cysteine building block for Fmoc solid-phase peptide synthesis in which the thiol group is protected with the acid-stable acetamidomethyl (Acm) group. The Acm protection is compatible with both Boc and Fmoc strategies and is removed by treatment with iodine or heavy-metal reagents after chain assembly.

Applications

Used in solid-phase peptide synthesis for the construction of multi-disulfide peptides and cysteine-containing peptide analogues requiring orthogonal thiol protection.

Product Overview

Because the Acm group survives standard trifluoroacetic acid cleavage, this derivative is particularly valuable for regioselective disulfide bond formation in peptides containing multiple cysteine residues.

CAS_No

86060-81-3

Molecular Weight

414.5

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

Fmoc-cysteine(acetamidomethyl); N-(9-fluorenylmethoxycarbonyl)-S-acetamidomethyl-L-cysteine

Molecular Formula

C21H22N2O5S

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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