Nα-Fmoc-sarcosine

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Cat No.

CEGZ-6910

Description

Nα-Fmoc-sarcosine is the Fmoc-protected form of sarcosine (N-methylglycine), the simplest N-methylated amino acid. It is used as a building block in Fmoc solid-phase peptide synthesis for the introduction of N-methylated residues.

Applications

Applied in solid-phase peptide synthesis for the preparation of N-methylated peptide analogues with improved pharmacological properties in medicinal chemistry and drug discovery research.

Product Overview

Backbone N-methylation of peptides disrupts hydrogen bonding patterns, increases conformational rigidity, improves membrane permeability, and enhances resistance to proteolytic degradation. Sarcosine residues are therefore widely used in the design of peptide-based drug candidates and occur in numerous peptide natural products.

CAS_No

77128-70-2

Molecular Weight

311.3

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

Fmoc-sarcosine; N-(9-fluorenylmethoxycarbonyl)-N-methylglycine; Fmoc-N-methylglycine

Molecular Formula

C18H17NO4

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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