Native Human Cathepsin D

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Cat No.

NATE-0172

Description

Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.

Abbr

CTSD, Native (Human)

Alias

CTSD; CPSD

Source

Human liver

Species

Human

Form

lyophilized powder

Enzyme Commission Number

EC 3.4.23.5

Activity

> 250 units/mg protein (E1%/280)

CAS_No

9025-26-7

Unit Definition

One unit will produce an increase in A280 of 1.0 in 30 min at pH 3.3 at 37°C measured as TCA-soluble products using acid-denatured hemoglobin as substrate (1 cm light path).

Storage

−20°C

Pathway

Ceramide signaling pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; LKB1 signaling events, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem

Function

aspartic-type endopeptidase activity; peptidase activity

Synonyms

CTSD; cathepsin D; CLN10; CPSD; HEL-S-130P; EC 3.4.23.5; 9025-26-7

"CTSD" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1707	Cathepsin D from Human, recombinant	EC 3.4.23.5	9025-26-7	E. coli	Inquiry
NATE-1874	Native Human Cathepsin D	EC 3.4.23.5	9025-26-7	Human Spleen	Inquiry
NATE-0171	Native Bovine Cathepsin D	EC 3.4.23.5	9025-26-7	Bovine spleen	Inquiry
EXWM-4287	cathepsin D	EC 3.4.23.5	9025-26-7		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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