Native Porcine Dipeptidyl Peptidase IV

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Cat No.

NATE-0203

Description

Native DPPIV is a ubiquitous type II transmembrane glycoprotein and a serine protease of the S9 prolyl-oligopeptidase family. In vivo, it is synthesized with a signal peptide, which functions as the membrane anchoring domain. There is an 88% sequence homology between the human and porcine kidney enzymes. Both exist as homodimers with a subunit molecular weight of ~30 kDa. The high mannose 100 kDa DPPIV precursor is processed in the Golgi to yield a 124 kDa heavily N-and O-linked mature glycoprotein. It is then sorted to the apical membrane through the concerted action of both N-and O-linked glycans and its association with lipid microdomains. The porcine enzyme contains 18.3% carbohydrates, which the glycan composition is 0.9% fucose, 3.4% mannose, 5.1% galactose, 8.2% glucosamine, and 0.7% sialic acid. DPPIV is highly expressed on endothelial cells, epithelial cells, and lymphocytes. It is also present in plasma in its soluble form.

Abbr

DPP4, Native (Porcine)

Alias

DPP4; DPPIV; CD26

Source

Porcine Kidney

Species

Porcine

Form

Liquid. In 20 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% NaN₃, pH 8.0.

Enzyme Commission Number

EC 3.4.14.5

Activity

1.0 U/mg; Specific Activity >40 U/mg protein

CAS_No

54249-88-6

Purity

>94% by SDS-PAGE

Unit Definition

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmole 7-(Gly-Pro)-amino-4-methylcoumarinamide per min at 37°C, pH 8.5.

Storage

at -70°C, Avoid freeze/thaw

Warnings

Dilute only the amount of enzyme needed for each assay. Upon thawing, do not re-freeze, store in the refrigerator (4°C).

Synonyms

EC 3.4.14.5; 54249-88-6; DPPIV; DPP4; dipeptidyl aminopeptidase IV; Xaa-Pro-dipeptidyl-aminopeptidase; Gly-Pro naphthylamidase; postproline dipeptidyl aminopeptidase IV; lymphocyte antigen CD26; glycoprotein GP110; dipeptidyl peptidase IV; glycylproline aminopeptidase; glycylproline aminopeptidase; X-prolyl dipeptidyl aminopeptidase; pep X; leukocyte antigen CD26; glycylprolyl dipeptidylaminopeptidase; dipeptidyl-peptide hydrolase; glycylprolyl aminopeptidase; dipeptidyl-aminopeptidase IV; DPP IV/CD26; amino acyl-prolyl dipeptidyl aminopeptidase; T cell triggering molecule Tp103; X-PDAP

"DPP IV" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0204	Dipeptidyl Peptidase IV from Human, Recombinant	EC 3.4.14.5	54249-88-6	Baculovirus infected Sf9 cells	Inquiry
NATE-0962	Native Human Dipeptidyl Peptidase-4	EC 3.4.14.5		Human Placenta	Inquiry
EXWM-4050	dipeptidyl-peptidase IV	EC 3.4.14.5	54249-88-6		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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