Necrostatin 2

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Cat No.

CEI-1442

Description

Necrostatin-2 (Nec-2) is a small molecule inhibitor ofRIPK2 kinase activity

Product Overview

Necrostatin 2 (Nec-2) is a novel and potent necroptosis inhibitor with EC50 of 50 nM. It is an analog of necrostatin 1 (nec-1). Necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented. Nec-2 is efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. There is limited record for Nec-2, but some reports are related with other necrostatins. Nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP1 in vitro.

CAS_No

852391-19-6

Molecular Weight

277.71

Purity

0.98

Storage

Store at -20°C

Synonyms

MTH-DL-Tryptophan, Necroptotic Inhibitor

Targets

RIPK2

Molecular Formula

C13H12ClN3O2

Chemical Name

(5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione

Solubility

Soluble in DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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