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NSC 146109 hydrochloride
Cat No.
CEI-0716
Description
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
Alias
XI-011
Appearance
Yellow solid
Product Overview
A p53 activator
CAS No.
59474-01-0
Molecular Weight
396.83
Purity
>95%
Storage
-20 centigrade
Synonyms
XI-011
Targets
p53
Molecular Formula
C₁₇H₁₆N₂S.HCl
Chemical Name
(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Solubility
DMSO (>5 mg/ml)
Shipping Conditions
Gel pack
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