NSC-207895 (XI-006)

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Cat No.

CEI-0177

Description

NSC-207895 can inhibit MDMX with IC50 of 2.5 uM.

CAS_No

58131-57-0

Molecular Weight

279.25

Purity

>99%

Storage

2 years at -20 centigrade

Targets

MDMX

Molecular Formula

C11H13N5O4

Chemical Name

2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide

Solubility

DSMO 0.4 mg/mL Water

In vitro

NSC-207895 decreases both the MDMX mRNA and protein in MCF-7 cells. NSC-207895 induces expression of p53 as well as well-characterized p53-target gene, p21 and MDM2, in a dose-dependent manner in MCF-7 cells. NSC-207895 increases the mRNA levels of proapoptotic genes including PUMA, BAX, and PIG3 in a dose-dependent manner in MCF-7 cells. NSC-207895 acts as cytotoxic agent in the G/R-luc astrocytoma cell line with GI50 of 117 nM.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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