NVP-ADW742

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Cat No.

CEI-0008

Description

NVP-ADW742 can inhibit the insulin-like growth factor-I receptor with IC50 of around 100 nM to 200 nM

Alias

ADW742

CAS_No

475488-23-4

Molecular Weight

453.58

Purity

>99%

Storage

2 years at -20 centigrade

Synonyms

ADW742

Targets

Insulin-like growth factor-I receptor

Molecular Formula

C28H31N5O

Chemical Name

5-(3-(benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Solubility

DSMO 10 mg/mL Water

In vitro

NVP-ADW742 can inhibit the insulin-like growth factor-I receptor with IC50 of around 100 nM to 200 nM. NVP-ADW742 is a potent and selective IGF-IR kinase inhibitor that can efficiently inhibit the growth of cells that are highly dependent on IGF-I signaling. By inhibiting IGF-IR signaling, NVP-ADW742 can inhibit the growth of H526 cell line with IC50 of 0.4 mM. SCF-mediated Kit phosphorylation and Akt activation were inhibited with IC(50) values in the 1-5 mM.

In vivo

NVP-ADW742 monotherapy or its combination with cytotoxic chemotherapy had significant antitumor activity in an orthotopic xenograft MM model, providing in vivo proof of principle for therapeutic use of selective IGF-1R inhibitors in cancer.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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