NVP-BSK805

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Cat No.

CEI-0200

Description

NVP-BSK805

CAS_No

1092499-93-8(freebase)

Molecular Weight

563.47

Purity

>99%

Storage

2 years at -20 centigrade

Targets

JAK2

Molecular Formula

C27H28F2N6O.2HCl

Solubility

In vitro

NVP-BSK805 can potently suppress JAK2 with IC50 of 0.5 nM, and displays more than 20-fold selectivity towards JAK1, JAK3, and TYK2. NVP-BSK805 shows inhibition to causes JAK2V617F and JAK2 wild-type with IC50 of 0.5 nM. For cell lines, NVP-BSK805 inhibt JAK2V617F cells (Ba/F3) growth and induce cell apoptosis. NVP-BSK805 also can potently inhibit STAT5. By inducing activation of caspase cascades, NVP-BSK805 triggered cell death.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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