ON-01910

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Cat No.

CEI-0303

Description

ON 01910 can inhibit polo-like kinase 1 (Plk1) with IC50 of 9 nM.

CAS_No

1225497-78-8

Molecular Weight

473.47

Purity

>99%

Storage

2 years at -20 centigrade

Targets

PLK1

Molecular Formula

C21H24NNaO8S

Solubility

DSMO Water Ethanol

In vitro

ON 01910 is a novel polo-like kinase 1 (Plk1) inhibitor and it inhibit PLK1 with IC50 of 9 nM. ON 01910 also shows cytotoxic activity against a variety of human tumor cell lines in vitro. ON 01910 can induce three major abnormalities in tumor cells, including abnormal cell division (irregular chromosomal segregation and cytokinesis), G2-M arrest and apoptosis, and decreased expression of Cdc25C in many tumor cell lines.

In vivo

In rats, single doses of 300 and 600 mg/m 2 of ON01910 produced no toxicity, and 1200 mg/m2 had only slight toxicity. There was no evidence of significant myelotoxicity, neuropathy, or cardiotoxicity in these toxicology studies. In xenograft mouse model systems, ON01910 inhibited the growth of a wide variety of human tumors, including liver, breast, and pancreatic cancers.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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