pappalysin-1

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Cat No.

EXWM-4363

Description

A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43.

Form

Liquid or lyophilized powder

Enzyme Commission Number

EC 3.4.24.79

Storage

Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.

Synonyms

insulin-like growth factor binding protein-4 protease; pregnancy-associated plasma protein-A

Reaction

Cleavage of the Met135┼Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143┼Lys bond in IGFBP-5

Notes

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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