PD153035 HCL

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Cat No.

CEI-0016

Description

PD153035 can inhibit epidermal growth factor (EGF) receptor tyrosine kinase with Ki of 6 pM.

CAS_No

183322-45-4

Molecular Weight

396.67

Purity

>99%

Storage

2 years at -20 centigrade

Targets

EGFR

Molecular Formula

C16H14BrN3O2.HCl

Chemical Name

N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

Solubility

DSMO 0.5 mg/mL Water

In vitro

PD153035 can inhibit epidermal growth factor (EGF) receptor tyrosine kinase with Ki of 6 pM. PD153035 can potently suppresses tyrosine phosphorylation of the EGF receptor in A431 cells at nanomolar concentrations. PD153035 inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and clonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines. EGF receptor autophosphorylation in response to exogenous EGF was completely inhibited at PD153035 concentrations of >75 nM in cells overexpressing the EGF receptor.

In vivo

In A431 human epidermoid tumors grown as xenografts in immunodeficient nude mice, PD153035(80 mg/kg) suppresse the tyrosine phosphorylation of the EGF receptor rapidly by 80-90% in the tumors.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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