Pemetrexed (Alimta)

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Cat No.

CEI-0323

Description

Pemetrexed disodium (Alimta) can inhibit TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM.

Alias

LY-231514

CAS_No

150399-23-8

Molecular Weight

471.37

Purity

>99%

Storage

2 years at -20 centigrade

Synonyms

LY-231514

Targets

Molecular Formula

C20H19N5Na2O6

Chemical Name

sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate

Solubility

DSMO 1 mg/ml Water 94 mg/mL Ethanol

In vitro

Pemetrexed disodium (Alimta) can inhibit TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM. Cisplatin plus Pemetrexed combined with SOCS-1 gene delivery shows the antitumor effect by inhibition of cell proliferation, invasiveness, and induction of apoptosis in MPM cells

In vivo

Pemetrexed disodium produces a duration-dependent tumor growth delay (TGD) in the human H460 non-small cell lung carcinoma xenograft.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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