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Perindopril Erbumine
Cat No.
CEI-0345
Description
Perindopril Erbumine
Alias
Aceon, Perindopril, Coversyl
CAS No.
131740-09-5
Molecular Weight
441.6
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
Aceon, Perindopril, Coversyl
Targets
ACE
Molecular Formula
C21H20ClNO5.HCl
Chemical Name
2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride
Solubility
DMSO 88 mg/mL, Water
In vitro
Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzyme (ACE) with bradykiningiotensin I selectivity ratio of 1.44. Perindopril Erbumine inhibits the angiotensin- and Abeta42-to-Abeta40-converting activity of mutated ACE containing two active domains (F-ACE) with IC50 of 0.03-0.1 uM, and 0.01-0.03 uM, respectively. Perindopril Erbumine (~2 uM) displays no significant cytotoxicity towards SCC-VII and KB cells, but can significantly reduce the production of angiotensin II and the transcription of VEGF in KB cells in a concentration-dependent manner.
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