Perindopril Erbumine

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Cat No.

CEI-0345

Alias

Aceon, Perindopril, Coversyl

CAS_No

131740-09-5

Molecular Weight

441.6

Purity

>99%

Storage

2 years at -20centigrade Powder

Synonyms

Aceon, Perindopril, Coversyl

Targets

ACE

Molecular Formula

C21H20ClNO5.HCl

Chemical Name

2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride

Solubility

DMSO 88 mg/mL, Water

In vitro

Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzyme (ACE) with bradykiningiotensin I selectivity ratio of 1.44. Perindopril Erbumine inhibits the angiotensin- and Abeta42-to-Abeta40-converting activity of mutated ACE containing two active domains (F-ACE) with IC50 of 0.03-0.1 uM, and 0.01-0.03 uM, respectively. Perindopril Erbumine (~2 uM) displays no significant cytotoxicity towards SCC-VII and KB cells, but can significantly reduce the production of angiotensin II and the transcription of VEGF in KB cells in a concentration-dependent manner.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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