PH-797804

inquiry

Cat No.

CEI-0157

Description

PH-797804 can inhibit p38 alpha with IC50 of 26 nM.

CAS_No

586379-66-0

Molecular Weight

477.3

Purity

>99%

Storage

2 years at -20 centigrade

Targets

p38 alpha

Molecular Formula

C22H19BrF2N2O3

Chemical Name

3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide

Solubility

DSMO 96 mg/mL Water

In vitro

PH-797804 is a highly selective inhibitor of p38-alpha kinase with IC50 of 26 nM. PH-797804 can block the production of cytokines and proinflammatory mediators. PH-797804 was potent and efficacious in blocking cellular p38 kinase activity along with biological responses in human cells associated with inflammation in the arthritic joint. PH-797804 can inhibit LPS-stimulated TNF- alpha production and p38 kinase activity with IC50 of 5.9 and 1.1 nM.

In vivo

PH-797804 can suppress chronic inflammation in both an inflammatory arthritis model in rats induced by SCW extract and in the widely used mouse collageninduced arthritis model. Doses of 0.5 to 5 mg/kg PH-797804 produced almost complete protection of the joint against inflammation-related bone density loss, whereas doses of 0.05 and 0.15 mg/kg were partially efficacious.

Name:

Email *

Phone:*

Company/Institution:

Country or Region:

Quantity:

Services & Products Interested *

Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Products

Online Inquiry