PHA-680632

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Cat No.

CEI-0335

Description

PHA-680632

CAS_No

398493-79-3

Molecular Weight

501.62

Purity

>99%

Storage

2 years at -20 centigrade

Targets

Aurora A

Molecular Formula

C28H35N7O2

Solubility

In vitro

PHA-680632 potently inhibits all three Aurora kinases (A, B, and C) with IC50 values of 27, 135, and 120 nM, respectively. PHA-680632 (0.5 uM) causes polyploidy in tumor cells. The mechanism of action of PHA-680632 is in agreement with inhibition of Aurora kinases. PHA680632 in association with radiation leads to additive effects in cancer cells, especially in the p53-deficient cells.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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