PIK-75

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Cat No.

CEI-0135

Description

PIK-75 can inhibit p110 alpha and DNA-PK with IC50 of 5.8 nM and 2 nM.

CAS_No

372196-77-5

Molecular Weight

488.74

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

p110 alpha, DNA-PK

Molecular Formula

C16H14BrN5O4S.HCl

Chemical Name

(E)-N-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride

Solubility

DMSO 3 mg/mL Water

In vitro

PIK-75 is a selective inhibitors of p110 alpha. PIK-75 can block the phosphorylation of PKB (akt) induced by insulin on both Ser 473 and Thr 308 in CHO-IR cells in a dose-dependent manner with an IC 50 of 78 nM. In 3T3-L1 pre-adipocytes, inhibition of p110-alpha by PIK-75 decreases the insulin-induced phosphorylation of PKB on both sites (Ser 473 and Thr 308 ).

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Project Description:

For research and industrial use only, not for personal medicinal use.

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