Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
pikromycin synthase
Cat No.
EXWM-0784
Description
A heme-thiolate protein (cytochrome P-450). Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin.
Form
Liquid or lyophilized powder
Enzyme Commission Number
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
PikC; CYP107L1
Reaction
(1) narbomycin + NADPH + H+ + O2 = pikromycin + NADP+ + H2O; (2) narbomycin + NADPH + H+ + O2 = neopikromycin + NADP+ + H2O; (3) narbomycin + 2 NADPH + 2 H+ + 2 O2 = novapikromyin + 2 NADP+ + 2 H2O; (4) 10-deoxymethymycin + NADPH + H+ + O2 = methymycin + NADP+ + H2O; (5) 10-deoxymethymycin + NADPH + H+ + O2 = neomethymycin + NADP+ + H2O; (6) 10-deoxymethymycin + 2 NADPH + 2 H+ + 2 O2 = novamethymycin + 2 NADP+ + 2 H2O
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Download
Download Datasheet