Plumbagin

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Cat No.

CEI-0397

Description

A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.

Alias

5-Hydroxy-2-methyl-1, 4-naphthalenedione

Appearance

Pale yellow solid

Product Overview

A potent histone acetyltransferase (HAT) inhibitor

CAS_No

481-42-5

Molecular Weight

384.27

Purity

>98% by TLC

Storage

-20 centigrade

Synonyms

5-Hydroxy-2-methyl-1,4-naphthalenedione

Targets

Akt, mTOR

Molecular Formula

C11H8O3

Chemical Name

5-Hydroxy-2-methyl-1,4-naphthalenedione

Solubility

DMSO (40 mg/ml) or EtOH (25 mg/ml)

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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